Patients self-treat with parasitic worms

Immunity to Parasitic Worms

Helminth infection provides a unique challenge to the host immune system. Not only are helminths complex multicellular organisms, but they have intricate life cycles with multiple developmental stages, several of which may coexist in the infected host. In most cases, the host response to helminth infection is characterized by eosinophilia, increased serum immunoglobulin (Ig) E and IgG4, and mas...

The Challenge of Parasitic Worms

Parasitic worms and inflammatory diseases

The debate on whether infection precipitates or prevents autoimmunity remains a contentious one. Recently the suggestion that some unknown microbe can be at the origin of some chronic inflammatory diseases has been countered by accumulating evidence that decreasing infection rates might have an important role to play in the rising prevalence of autoimmune disorders. The 'Hygiene Hypothesis' was...

Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms

The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend's hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that ...

The Parasitic Worms of Man and the Domestic Animals